HCID 86656614、化合物 → N-Hydroxy-2-(4-methylbenzoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide
反応式
[CH3:1][C:2]1[CH:29]=[CH:28][C:5]([C:6]([N:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][C:12]([C:18]([NH:20][O:21]C4CCCCO4)=[O:19])=[CH:13][CH:14]=3)[CH2:9]2)=[O:7])=[CH:4][CH:3]=1>CO.Cl>[OH:21][NH:20][C:18]([C:12]1[CH:11]=[C:10]2[C:15]([CH2:16][CH2:17][N:8]([C:6](=[O:7])[C:5]3[CH:28]=[CH:29][C:2]([CH3:1])=[CH:3][CH:4]=3)[CH2:9]2)=[CH:14][CH:13]=1)=[O:19]参加物
4
実験手順
A mixture of 70 mg 2-(4-methylbenzoyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide in 6 ml methanol and 6 ml 0.1 N aqueous hydrochloric acid is stirred overnight at ambient temperature. Subsequently, the reaction mixture is evaporated. The residue is dissolved in a mixture of water and acetonitrile and lyophilized. The crude product is further purified by silica gel flash chromatography. 11 mg of the title compound are obtained as colorless solid. MH+=311.1