Water → 2-Hydroxy-4-phenylthiazole
反応式
[C:1]1([C:7](=O)[CH2:8][S:9][C:10]#[N:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:13]S(O)(=O)=O.O>CC(O)=O>[C:1]1([C:7]2[NH:11][C:10](=[O:13])[S:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
5
実験手順
To a solution of 1-phenyl-2-thiocyanato-ethanone (20 g, 113 mmol) in HOAc (100 mL) was added 50% aqueous H2SO4 (20 mL). The mixture was refluxed for 10 min. The mixture was poured into water. The solid formed was collected by filtration to give crude 4-phenyl-3H-thiazol-2-one (20 g) which was used for the next step without further purification.
後処理
- temperatureThe mixture was refluxed for 10 min
- customThe solid formed
- filtrationwas collected by filtration
出典と根拠
- ORDレコード
- ord-24148e6e66124618a3b0215e91a63f63
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08575156B2
反応ノート
読み込み中…