Phosphorus oxychloride → 2-Chloro-4-phenylthiazole

反応式

[C:1]1([C:7]2[NH:8][C:9](=O)[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O=P(Cl)(Cl)[Cl:15]>>[Cl:15][C:9]1[S:10][CH:11]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:8]=1

参加物

反応物 2

HCID 24813Phosphorus oxychloride

HCID 6989032-Hydroxy-4-phenylthiazole

生成物 1

HCID 27613592-Chloro-4-phenylthiazole収率 57%

実験手順

4-Phenyl-3H-thiazol-2-one (5 g, 28.2 mmol) was dissolved in POCl3 (30 mL), and the mixture was refluxed overnight. The mixture was concentrated in vacuum, and the residue was purified by column chromatography to give 2-chloro-4-phenylthiazole (3.1 g, 57%).

後処理

temperaturethe mixture was refluxed overnight
concentrationThe mixture was concentrated in vacuum
customthe residue was purified by column chromatography

出典と根拠

ORDレコード: ord-1cc5365b28cf420f811c50c15b2f1e98
出典データセット: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08575156B2

反応ノート

読み込み中…

参加物