Methanol → HCID 57869857、化合物

HRID 2038617ノート

反応式

HRID 2038617 の反応式
CO[C:3](=[O:13])[CH2:4][CH2:5][O:6][N:7]=[C:8]([O:10][CH2:11][CH3:12])[CH3:9].[CH3:14][NH2:15].[CH3:16]O>>[CH2:11]([O:10][C:8](=[N:7][O:6][CH2:5][CH2:4][C:3](=[O:13])[NH:15][CH2:14][CH3:16])[CH3:9])[CH3:12]

参加物

4

反応物 3

HCID 887MethanolHCID 6329MethylamineHCID 71331645Methyl 3-{[(1-ethoxyethylidene)amino]oxy}propanoate

生成物 1

HCID 57869857HCID 57869857、化合物収率 57%

反応条件

温度
60 °C

実験手順

To a known compound, 3-(1-ethoxyethylideneaminooxy)-propanoic acid methyl ester (CAS No. 97164-30-2, 300 mg, 1.585 mmol) was added a 2 M solution of methylamine in methanol (7 ml), and the mixture was stirred at 60° C. for 13 hours. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to give N-(2-ethylcarbamoyl-ethoxy)-acetimidic acid ethyl ester (182 mg, 57% yield).

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-889bd530afc949de9b3e9d4632c9f1dc
出典データセット
uspto-grants-2013_11
特許番号
US08575391B2

反応ノート

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