Triethylamine → 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-(2-oxo-tetrahydro-pyrimidin-1-ylmethyl)-benzamide

HRID 2038656

反応式

HRID 2038656 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][NH:5][CH2:6][C:7]1[C:8]([F:30])=[C:9]([F:29])[C:10]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([I:27])=[CH:23][C:22]=2[F:28])=[C:11]([CH:19]=1)[C:12]([NH:14][O:15][CH2:16][CH2:17][OH:18])=[O:13].C1C(=O)N(OC(ON2C(=O)CCC2=O)=O)[C:33](=[O:34])C1.C(N(CC)CC)C>C1COCC1.CC#N>[F:29][C:9]1[C:10]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([I:27])=[CH:23][C:22]=2[F:28])=[C:11]([CH:19]=[C:7]([CH2:6][N:5]2[CH2:4][CH2:3][CH2:2][NH:1][C:33]2=[O:34])[C:8]=1[F:30])[C:12]([NH:14][O:15][CH2:16][CH2:17][OH:18])=[O:13]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 676246Di(succinimido) carbonateHCID 593479915-[(3-amino-propylamino)-methyl]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-benzamide

生成物 1

HCID 115704243,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-(2-oxo-tetrahydro-pyrimidin-1-ylmethyl)-benzamide収率 61.2%

試薬・触媒・溶媒 1

HCID 22177404Acetonitrile tetrahydrofuran溶媒

実験手順

The amine synthesized in Step A (66.4 mg, 0.1233 mmol) was dissolved in THF:CH3CN (1:1 v/v, 3.0 ml). N,N-disuccinimidyl carbonate (47.4 mg, 1.5 eq., 0.1849 mmol) and triethylamine (103.1 μl, 6.0 eq., 0.7398 mmol) were added sequentially to this solution, and the mixture was stirred at room temperature for 20 hours. The solvent was removed under reduced pressure, and the residue was purified by LC/MS to give white crystals (42.6 mg).

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe residue was purified by LC/MS

出典と根拠

ORDレコード
ord-cb017b8eb39d4e5ca03e452baacee576
出典データセット
uspto-grants-2013_11
特許番号
US08575391B2

関連ノート

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