Hydrochloric Acid → (R)-1-(6-bromo-pyridin-3-yl)-ethylamine HCl salt

HRID 2038751ノート

反応式

HRID 2038751 の反応式
[Br:1][C:2]1[N:7]=[CH:6][C:5]([C@H:8]([NH:10]S(C(C)(C)C)=O)[CH3:9])=[CH:4][CH:3]=1.[ClH:17].O1CCOCC1.CCOCC>CO>[ClH:17].[Br:1][C:2]1[N:7]=[CH:6][C:5]([C@H:8]([NH2:10])[CH3:9])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 312751,4-DioxaneHCID 889592202-methyl-propane-2-sulfinic acid[(R)-1-(6-bromo-pyridin-3-yl)-ethyl]-amide

生成物 1

HCID 53487712(R)-1-(6-bromo-pyridin-3-yl)-ethylamine HCl salt収率 87%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 2-methyl-propane-2-sulfinic acid[(R)-1-(6-bromo-pyridin-3-yl)-ethyl]-amide (650 mg, 2.13 mmol) in MeOH (5 mL) was added 4.0M HCl in dioxane (5.32 mL, 21.30 mmol). The clear reaction mixture was stirred at room temperature for 2.5 h. The reaction mixture became cloudy during this time. Ether (20 mL) was added, and the mixture was stirred for 10 min and then filtered, washed with ether (20 mL) to afford (R)-1-(6-bromo-pyridin-3-yl)-ethylamine HCl salt (500 mg, 87%) as a white solid.

後処理

  1. stirringthe mixture was stirred for 10 min
  2. filtrationfiltered
  3. washwashed with ether (20 mL)

出典と根拠

ORDレコード
ord-65baaa4f989049aaa2c3e6e1cb9a0a31
出典データセット
uspto-grants-2013_11
特許番号
US08575360B2

反応ノート

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