Hydrochloric Acid → {5-[6-(1-Amino-1-methyl-ethyl)-pyridazin-3-yl]-pyridin-2-yl}-methanol dihydrochloride

HRID 2038764ノート

反応式

HRID 2038764 の反応式
[OH:1][CH2:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[N:14]=[N:13][C:12]([C:15]([NH:18]S(C(C)(C)C)=O)([CH3:17])[CH3:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[ClH:25].O1CCOCC1>C(Cl)Cl>[ClH:25].[ClH:25].[NH2:18][C:15]([C:12]1[N:13]=[N:14][C:9]([C:6]2[CH:5]=[CH:4][C:3]([CH2:2][OH:1])=[N:8][CH:7]=2)=[CH:10][CH:11]=1)([CH3:17])[CH3:16]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 683789692-Methyl-propane-2-sulfinic acid{1-[6-(6-hydroxymethyl-pyridin-3-yl)-pyridazin-3-yl]-1-methyl-ethyl}-amide

生成物 1

HCID 67508792{5-[6-(1-Amino-1-methyl-ethyl)-pyridazin-3-yl]-pyridin-2-yl}-methanol dihydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-Methyl-propane-2-sulfinic acid{1-[6-(6-hydroxymethyl-pyridin-3-yl)-pyridazin-3-yl]-1-methyl-ethyl}-amide (4 mg, 0.011 mmol) was dissolved in CH2Cl2 (0.25 mL) and 4M HCl in dioxane (2 mL, 8 mmol) was added. After 45 minutes, the solvent was removed under a stream of N2 to give {5-[6-(1-amino-1-methyl-ethyl)-pyridazin-3-yl]-pyridin-2-yl}-methanol dihydrochloride as a crude light brown solid residue. This was used without further purification.

後処理

  1. customthe solvent was removed under a stream of N2

出典と根拠

ORDレコード
ord-84186f0e0a8f4faa86667d1e36f8b220
出典データセット
uspto-grants-2013_11
特許番号
US08575360B2

反応ノート

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