Dichloromethane → 1-[5-(1-Methyl-1H-pyrazol-4-yl)-pyridin-2-yl]-cyclopropylamine dihydrochloride

HRID 2038773ノート

反応式

HRID 2038773 の反応式
C(OC(=O)[NH:7][C:8]1([C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[N:19][N:20]([CH3:22])[CH:21]=3)=[CH:13][N:12]=2)[CH2:10][CH2:9]1)(C)(C)C.O1CCOCC1.C(Cl)[Cl:31]>Cl>[ClH:31].[ClH:31].[CH3:22][N:20]1[CH:21]=[C:17]([C:14]2[CH:15]=[CH:16][C:11]([C:8]3([NH2:7])[CH2:10][CH2:9]3)=[N:12][CH:13]=2)[CH:18]=[N:19]1

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 312751,4-Dioxane2 回HCID 67515892{1-[5-(1-methyl-1H-pyrazol-4-yl)-pyridin-2-yl]-cyclopropyl}-carbamic acid tert-butyl ester

生成物 1

HCID 683794491-[5-(1-Methyl-1H-pyrazol-4-yl)-pyridin-2-yl]-cyclopropylamine dihydrochloride

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒2 回

実験手順

To a solution of {1-[5-(1-methyl-1H-pyrazol-4-yl)-pyridin-2-yl]-cyclopropyl}-carbamic acid tert-butyl ester (1.1 g, 3.5 mmol) in CH2Cl2 (15 mL), 4.0M HCl in dioxane (4.35 mL, 17.5 mmol) was added. After stirring overnight, more 4.0M HCl in dioxane (4.35 mL, 17.5 mmol) was added to the solution. After another 12 hours, the solution was concentrated in-vacuo to yield 800 mg of the title compound.

後処理

  1. waitAfter another 12 hours
  2. concentrationthe solution was concentrated in-vacuo

出典と根拠

ORDレコード
ord-6dfe18c96a90465fad0bb0cc843bf65a
出典データセット
uspto-grants-2013_11
特許番号
US08575360B2

反応ノート

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