Hydrochloric Acid → (r)-1-(5-Bromo-pyridin-2-yl)-ethylamine dihydrochloride

HRID 2038782ノート

反応式

HRID 2038782 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]([NH:10][S@@](C(C)(C)C)=O)[CH3:9])=[N:6][CH:7]=1.[ClH:17].CCOCC>CO>[ClH:17].[ClH:17].[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]([NH2:10])[CH3:9])=[N:6][CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 68237516(R)-2-methyl-propane-2-sulfinic acid[(R)-1-(5-bromo-pyridin-2-yl)-ethyl]-amide

生成物 1

HCID 68378980(r)-1-(5-Bromo-pyridin-2-yl)-ethylamine dihydrochloride収率 101%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of (R)-2-methyl-propane-2-sulfinic acid[(R)-1-(5-bromo-pyridin-2-yl)-ethyl]-amide (500 mg, 1.64 mmol) in 5 mL of MeOH was added HCl (4.10 mL, 16.4 mmol, 4M in dioxane). The reaction mixture was stirred at room temperature for 2.5 h, during which time a white precipitate was formed. 20 mL of Et2O was added. After stirring for an additional 20 min, the reaction mixture was filtered, washing with 10 mL of Et2O. 454 mg (99%) of the title compound was isolated as a white solid after drying under high vacuum.

後処理

  1. customwas formed
  2. stirringAfter stirring for an additional 20 min
  3. filtrationthe reaction mixture was filtered
  4. washwashing with 10 mL of Et2O

出典と根拠

ORDレコード
ord-f4935b4666d0494eb6d8ebe19039638f
出典データセット
uspto-grants-2013_11
特許番号
US08575360B2

反応ノート

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