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4,4'-Ethylenedianiline → N-Boc-pyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,4'-Ethylenedianiline | HCID 12138 | — |
| 反応物 | 1(2H)-Quinolinecarboxylic acid, ethyl ester | HCID 27813 | — |
| 反応物 | 1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid | HCID 268472 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-Boc-pyrrolidine | HCID 643455 | 147.2% |
反応手順
4,4′-Ethylenedianiline (2.98 g) and pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (7.09 g) were dissolved in DCM (90 mL), and 1-ethoxycarbonyl-1,2-dihydroquinoline (8.38 g) was added. The reaction mixture was stirred at ambient temperature for 3 hours and evaporated under vacuum. Oil was dissolved in ethyl acetate, forming a precipitate, which was collected by vacuum filtration and dried under vacuum, giving 2-[4-(2-{4-[(1-carboxylic acid tert-butyl ester-pyrrolidine-2-carbonyl)-amino]-phenyl}-ethyl)-phenylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (8.30 g, 97%) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08575118B2 |
| 出典データセット | uspto-grants-2013_11 |
| ORD ID | ord-e828e3960633493085dd0898a7b9d36e |
| 出典メモ | uspto-grants-2013_11 |