Triethyl phosphite → Diethyl (4-Bromobenzyl)phosphonate

HRID 2039412ノート

反応式

HRID 2039412 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[P:10]([O:17]CC)([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13]>>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][P:10](=[O:17])([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 31215Triethyl phosphiteHCID 685274-Bromobenzyl bromide

生成物 1

HCID 11077666Diethyl (4-Bromobenzyl)phosphonate

実験手順

40.69 g (1 molar equivalent, 163 mmol) of 4-bromobenzyl bromide 1 are heated at 160° C. in 28.3 ml (1 molar equivalent, 163 mmol) of triethyl phosphite until the evolution of gas is complete. The batch is distilled in vacuo, and the residue remaining in the form of an oil 2 (48.87 g, 98%) is employed in the subsequent reaction without further purification.

後処理

  1. distillationThe batch is distilled in vacuo
  2. customis employed in the subsequent reaction without further purification

出典と根拠

ORDレコード
ord-57803490aa25423897ffcd1a9902dc71
出典データセット
uspto-grants-2013_11
特許番号
US08580395B2

反応ノート

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