反応式
[O:1]1[CH:6]=[CH:5][CH2:4][CH2:3][CH:2]1[NH2:7].[H][H]>CO>[O:1]1[CH:6]=[CH:5][CH2:4][CH2:3][CH:2]1[NH2:7].[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[NH2:7]参加物
実験手順
For example, hydrogenation of the dihydropyran-ene-amine to form the dihydropyran-amine may be accomplished in methanol, at 25° C., using about 88-110 psi hydrogen pressure, using 1-2 mol % of a catalyst generated from [Rh(nbd)2]BF4 and SL-M004-1 (SL-M004-1: (αR,αR)-2,2′-bis(α-N,N-dimethyl-aminophenylmethyl)-(S,S)-1,1′-bis[di(3,5-dimethyl-4-methoxyphenyl)phosphino]ferrocene, available from Solvias, Inc. Fort Lee, N.J.). Hydrogenation of the dihydropyran-amine to form the tetrahydropyran-amine may be accomplished at 50° C., using about 80 bar hydrogen pressure and 4 mol % catalyst loading of a catalyst generated from [Rh(COD)2]O3SCF3 and SL-A109-2 (solvent: THF) or [Rh(nbd)2]BF4 and SL-A109-2 (solvent: methanol) (SL-A109-2: (S)-(6,6′-dimethoxybiphenyl-2,2′-diyl)-bis[bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphine], available from Solvias, Inc. Fort Lee, N.J.).
出典と根拠
- ORDレコード
- ord-b3bb06b04cac47cb8a580c59ee17a863
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08580823B2
関連ノート
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