関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Neopentyl alcohol | HCID 6404 | — |
| 反応物 | Pyruvic aldehyde dimethyl acetal | HCID 80650 | — |
| 触媒 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 生成物 | 1,1-Bis-(2,2-dimethylpropoxy)-propan-2-one | HCID 86236681 | 67.2% |
反応手順
Add p-toluenesulfonic acid hydrate (1.21 g, 10.58 mmol) to 1,1-dimethoxy-propan-2-one (25.00 g, 211.63 mmol) and neopentyl alcohol (46.64 g, 529.08 mmol) at room temperature. Heat in an open flask in an 80° C. oil bath for 8 hours. Allow to cool to room temperature and stir over the weekend. Purify (silica gel chromatography, eluting with 0:100 to 8:92 ethyl acetate:hexanes) to give the desired compound as a colorless oil (32.78 g 67.2%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07745438B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-91aa903b4a07429497e2bc7b6f8efa12 |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
