Hydrochloric Acid → 2,6-Dimethylisonicotinic acid hydrochloride

HRID 2040765ノート

反応式

HRID 2040765 の反応式
C([O:5][C:6](=[O:15])[C:7]1[CH:12]=[C:11]([CH3:13])[N:10]=[C:9]([CH3:14])[CH:8]=1)(C)(C)C.[ClH:16]>C(O)(C)C>[ClH:16].[CH3:13][C:11]1[CH:12]=[C:7]([CH:8]=[C:9]([CH3:14])[N:10]=1)[C:6]([OH:15])=[O:5]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 67027153tert-Butyl 2,6-dimethylisonicotinate

生成物 1

HCID 533934312,6-Dimethylisonicotinic acid hydrochloride

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

A solution of 2,6-dimethylisonicotinic acid tert.-butyl ester (2.37 g, 11.44 mmol) in 5 N HCl in isopropanol (40 mL) is stirred at 80° C. for 3 h. The solvent is evaporated and the crude product is purified by MPLC on silica gel (heptane:EA gradient) to give 2,6-dimethylisonicotinic acid hydrochloride as a beige resin; 1H NMR (CD3OD): δ 8.16 (s, 2H), 2.84 (s, 6H).

後処理

  1. customThe solvent is evaporated
  2. customthe crude product is purified by MPLC on silica gel (heptane:EA gradient)

出典と根拠

ORDレコード
ord-b685606f8505464ea7d6f17f8b303d7f
出典データセット
uspto-grants-2013_11
特許番号
US08580824B2

反応ノート

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