3-[(3-Chlorophenyl)ethynyl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-one → 3-(2-Phenylethynyl)-1-oxa-2-azaspiro[4.5]dec-2-en-8-one

HRID 2040872ノート

反応式

HRID 2040872 の反応式
Cl[C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH2:14][C:13]3([CH2:19][CH2:18][C:17](=[O:20])[CH2:16][CH2:15]3)[O:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1.C1(C#CC2CC3(CCC4(OCCO4)CC3)ON=2)C=CC=CC=1>>[C:4]1([C:8]#[C:9][C:10]2[CH2:14][C:13]3([CH2:19][CH2:18][C:17](=[O:20])[CH2:16][CH2:15]3)[O:12][N:11]=2)[CH:5]=[CH:6][CH:7]=[CH:2][CH:3]=1

参加物

3

反応物 2

HCID 566464673-[(3-Chlorophenyl)ethynyl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-oneHCID 56646683HCID 56646683、化合物

生成物 1

HCID 566466843-(2-Phenylethynyl)-1-oxa-2-azaspiro[4.5]dec-2-en-8-one

実験手順

The title compound was synthesized using the same method described for the compound of Example 32, but starting from the compound of Example 44 instead of the compound of Example 31. The crude was purified by automated flash chromatography (SP1®TM-Biotage; Petroleum Ether-EtOAc 8:2) to give the title product as white solid. Yield: 80%.

後処理

  1. customThe title compound was synthesized
  2. customThe crude was purified by automated flash chromatography (SP1®TM-Biotage; Petroleum Ether-EtOAc 8:2)

出典と根拠

ORDレコード
ord-3bf756c993954164bdc2a7b6f407dfbc
出典データセット
uspto-grants-2013_11
特許番号
US08580962B2

反応ノート

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