Methanol → (2-Fluoro-4-phenoxyphenyl)-methanol

HRID 2041340ノート

反応式

HRID 2041340 の反応式
[F:1][C:2]1[CH:15]=[C:14]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:13]=[CH:12][C:3]=1[CH2:4][O:5]C1CCCCO1.CO.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>CCOC(C)=O>[F:1][C:2]1[CH:15]=[C:14]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:13]=[CH:12][C:3]=1[CH2:4][OH:5]

参加物

5

反応物 3

HCID 887MethanolHCID 521998p-Toluenesulfonic acid monohydrateHCID 576563912-(2-Fluoro-4-phenoxy-benzyloxy)-tetrahydro-pyran

生成物 1

HCID 57656488(2-Fluoro-4-phenoxyphenyl)-methanol収率 95%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Mix under nitrogen atmosphere 2-(2-fluoro-4-phenoxy-benzyloxy)-tetrahydro-pyran (2.05 g, 6.8 mmol), methanol (60 mL) and p-toluenesulfonic acid monohydrate (260 mg, 1.35 mmol). Stir at ambient temperature for 16h. Dilute with EtOAc. Wash with saturated aqueous NaHCO3. Separate the organic layer, dry over Na2SO4 and concentrate in vacuo to give the desired intermediate (1.41 g, 95%). MS (ES+) m/z: 201 (M−OH)+.

後処理

  1. washWash with saturated aqueous NaHCO3
  2. customSeparate the organic layer
  3. dry with materialdry over Na2SO4
  4. concentrationconcentrate in vacuo

出典と根拠

ORDレコード
ord-079a7785ffe544e087f4fd046ee169fa
出典データセット
uspto-grants-2013_11
特許番号
US08580780B2

反応ノート

読み込み中…