Hydrochloric Acid → 3-Aminomethyl-6-cyclohexylmethyl-pyridine

HRID 2041525ノート

反応式

HRID 2041525 の反応式
Cl.C(OC([NH:9][CH2:10][C:11]1[CH:12]=[N:13][C:14]([CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[CH:15][CH:16]=1)=O)(C)(C)C.CCCCCC>O1CCOCC1.CCOC(C)=O>[NH2:9][CH2:10][C:11]1[CH:12]=[N:13][C:14]([CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[CH:15][CH:16]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 8058HexaneHCID 576559013-Tert-butoxycarbonylaminomethyl-6-cyclohexylmethyl-pyridine

生成物 1

HCID 576566033-Aminomethyl-6-cyclohexylmethyl-pyridine収率 97%

試薬・触媒・溶媒 2

HCID 8857Ethyl Acetate溶媒HCID 312751,4-Dioxane溶媒

実験手順

Add 4N hydrogen chloride in dioxane (10 mL) to a solution of 3-tert-butoxycarbonylaminomethyl-6-cyclohexylmethyl-pyridine (345 mg, 1.13 mmol) in EtOAc (10 mL) and stir overnight. Concentrate in vacuo, suspend the solid obtained in diethyl ether and add hexane. Filter and wash the solid with hexane. Suspend the solid into dichloromethane, add saturated aqueous NaHCO3 and stir until both phases are clear (15 min). Extract the aqueous phase twice with dichoromethane. Dry the combined organic extracts over MgSO4, filter and concentrate in vacuo to obtain the title compound as an oil (205 mg, 97%) that was used without any further purification. MS (ES+) n7/z: 205 (M+H)+.

後処理

  1. concentrationConcentrate in vacuo
  2. customobtained in diethyl ether
  3. filtrationFilter
  4. washwash the solid with hexane
  5. additionadd saturated aqueous NaHCO3
  6. stirringstir until both phases
  7. custom(15 min)
  8. extractionExtract the aqueous phase twice with dichoromethane
  9. dry with materialDry the combined organic extracts over MgSO4
  10. filtrationfilter
  11. concentrationconcentrate in vacuo

出典と根拠

ORDレコード
ord-681bc10dd7f844428b852803deb0f9f8
出典データセット
uspto-grants-2013_11
特許番号
US08580780B2

反応ノート

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