Hydrochloric Acid → 3-(2-Tert-butylphenylthio)azetidine hydrochloride
反応式
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11][CH:12]1[CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13]1)([CH3:4])([CH3:3])[CH3:2].[ClH:23]>O1CCOCC1>[ClH:23].[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11][CH:12]1[CH2:13][NH:14][CH2:15]1)([CH3:4])([CH3:2])[CH3:3]参加物
4
実験手順
To a stirred solution of tert-butyl 3-(2-tert-butylphenylthio)azetidine-1-carboxylate (1.70 g, 5.29 mmol) in dioxane (5.0 mL) was added hydrogen chloride (5.3 mL of 4.0 M solution in dioxane, 21.2 mmol) at room temperature. After 24 h the reaction mixture was concentrated under reduced pressure and the resulting residue was triturated with diethyl ether to provide 3-(2-tert-butylphenylthio)azetidine hydrochloride (1.18 g, 87%) as a white solid.
後処理
- concentrationAfter 24 h the reaction mixture was concentrated under reduced pressure
- customthe resulting residue was triturated with diethyl ether
出典と根拠
- ORDレコード
- ord-5a2c41fddc9e479c8c2d3348046f272f
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08586571B2
反応ノート
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