Hydrochloric Acid → HCID 53409533、化合物

HRID 2041964ノート

反応式

HRID 2041964 の反応式
[C:1]([C:5]1[CH:23]=[CH:22][CH:21]=[CH:20][C:6]=1[O:7][CH:8]1[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[ClH:24]>O1CCOCC1>[ClH:24].[C:1]([C:5]1[CH:23]=[CH:22][CH:21]=[CH:20][C:6]=1[O:7][CH:8]1[CH2:12][CH2:11][NH:10][CH2:9]1)([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 59577147HCID 59577147、化合物

生成物 1

HCID 53409533HCID 53409533、化合物収率 83%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A stirred solution of tert-butyl 3-(2-tert-butylphenoxy)pyrrolidine-1-carboxylate (0.78 g, 2.44 mmol) and hydrochloric acid (7.0 mL of a 4.0 N solution in dioxane, 28.0 mmol) was reacted at room temperature for 16 h. Then, the reaction mixture was concentrated under reduced pressure. The residue was triturated with ethyl acetate to provide 3-(2-tert-butylphenoxy)pyrrolidine hydrochloride as a colorless solid (0.52 g, 83%).

後処理

  1. concentrationThen, the reaction mixture was concentrated under reduced pressure
  2. customThe residue was triturated with ethyl acetate

出典と根拠

ORDレコード
ord-f014bae3f44241d68b139b214acb94e5
出典データセット
uspto-grants-2013_11
特許番号
US08586571B2

反応ノート

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