3-Bromo-5-chloropyridine → 2-tert-Butyl-6-(5-chloro-pyridin-3-ylethynyl)-pyrazolo[1,5-a]pyrimidine

反応式

[C:1]([C:5]1[CH:15]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[CH:14])=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2].Br[C:17]1[CH:18]=[N:19][CH:20]=[C:21]([Cl:23])[CH:22]=1>>[C:1]([C:5]1[CH:15]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[C:14][C:17]3[CH:18]=[N:19][CH:20]=[C:21]([Cl:23])[CH:22]=3)=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

反応物 2

HCID 6062563-Bromo-5-chloropyridine

HCID 583167022-tert-Butyl-6-ethynyl-pyrazolo[1,5-a]pyrimidine

生成物 1

HCID 532473302-tert-Butyl-6-(5-chloro-pyridin-3-ylethynyl)-pyrazolo[1,5-a]pyrimidine

実験手順

The title compound, light yellow solid, MS: m/e=311.2 (M+H+), can be prepared in accordance with the general method of example 1 from 2-tert-butyl-6-ethynyl-pyrazolo[1,5-a]pyrimidine (example 21, step 2) and 3-bromo-5-chloropyridine.

出典と根拠

ORDレコード: ord-a06117ae274a466d91ed70acc9675d82
出典データセット: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08586581B2

反応ノート

読み込み中…