3-Chloropropanesulphonyl chloride → 3-Chloro-N-(3-(2-chloro thieno[3,2-d]pyrimidin-7-yl)phenyl)propane-1-sulfonamide
反応式
[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[S:10][CH:9]=[C:8]([C:11]3[CH:12]=[C:13]([NH2:17])[CH:14]=[CH:15][CH:16]=3)[C:6]=2[N:7]=1.[Cl:18][CH2:19][CH2:20][CH2:21][S:22](Cl)(=[O:24])=[O:23]>>[Cl:18][CH2:19][CH2:20][CH2:21][S:22]([NH:17][C:13]1[CH:14]=[CH:15][CH:16]=[C:11]([C:8]2[C:6]3[N:7]=[C:2]([Cl:1])[N:3]=[CH:4][C:5]=3[S:10][CH:9]=2)[CH:12]=1)(=[O:24])=[O:23]参加物
3
実験手順
3-Chloro-N-(3-(2-chloro thieno[3,2-d]pyrimidin-7-yl)phenyl)propane-1-sulfonamide (240 mg, 78% yield) was prepared in the same manner as Step 7 of Example 1 using 3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)benzenamine (200 mg, 0.76 mmol) and 3-chloropropane-1-sulfonyl chloride (145 mg, 0.84 mmol).
出典と根拠
- ORDレコード
- ord-a9052f787be24fdfaedfd9c938223db5
- 出典データセット
- uspto-grants-2013_11