HCID 178478593、化合物 → HCID 178520750、化合物
反応式
Cl.Cl.Cl.[S:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH:6]=[CH:5]1.C[O:29][C:30](=O)[CH2:31][C@H:32]1[CH2:37][CH2:36][C@H:35]([OH:38])[CH2:34][CH2:33]1>>[OH:38][C@H:35]1[CH2:36][CH2:37][C@H:32]([CH2:31][C:30]([NH:27][C@H:24]2[CH2:25][CH2:26][C@H:21]([CH2:20][CH2:19][N:16]3[CH2:17][CH2:18][N:13]([C:8]4[C:7]5[CH:6]=[CH:5][S:4][C:12]=5[CH:11]=[CH:10][N:9]=4)[CH2:14][CH2:15]3)[CH2:22][CH2:23]2)=[O:29])[CH2:33][CH2:34]1参加物
3
実験手順
The title compound was prepared in analogy to example 2 starting from trans-4-[2-(4-thieno[3,2-c]pyridin-4-yl-piperazin-1-yl)-ethyl]-cyclohexylamine trihydrochloride (intermediate B) (1150 mg, 0.33 mmol) and trans-(4-hydroxy-cyclohexyl)-acetic acid methyl ester [CAS-Nr. 1124174-16-8, WO 2010/031735] (68 mg, 0.39 mmol). Purification by flash chromatography on silica gel (CH2Cl2/MeOH 95:5). White crystals (83 mg, 52%), MS (ISP) m/z=485.4 [(M+H)+].
後処理
- customPurification by flash chromatography on silica gel (CH2Cl2/MeOH 95:5)
出典と根拠
- ORDレコード
- ord-fd7dd8147fea4078b99bb705728bd36f