Boron tribromide → HCID 56946411、化合物

HRID 2042550ノート

反応式

HRID 2042550 の反応式
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:14]([CH3:15])=[N:13][N:12]([CH3:16])[C:11](=[O:17])[CH:10]=2)=[CH:5][CH:4]=1.B(Br)(Br)Br>C(Cl)Cl>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:14]([CH3:15])=[N:13][N:12]([CH3:16])[C:11](=[O:17])[CH:10]=2)=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 25134Boron tribromideHCID 56946410HCID 56946410、化合物

生成物 1

HCID 56946411HCID 56946411、化合物収率 22%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of the product from step 1 (3.2 g, 14 mmol) in CH2Cl2 (40 mL) was cooled to 0° C. and BBr3 (6.6 mL, 5.0 eq.) was added dropwise. The ice-bath was removed and the reaction was stirred at rt for 1 h, after which the reaction mixture was poured into 50 mL of ice cold saturated NH4Cl solution with stirring. The resulting solid was filtered, and washed with water (3×15 mL) then Et2O (2×15 mL) to give the product of step 2 (0.66 g, 22%): MS m/z 217 (M+H).

後処理

  1. customThe ice-bath was removed
  2. additionafter which the reaction mixture was poured into 50 mL of ice cold saturated NH4Cl solution
  3. stirringwith stirring
  4. filtrationThe resulting solid was filtered
  5. washwashed with water (3×15 mL)

出典と根拠

ORDレコード
ord-e5615837800942998c2e5a03820cccca
出典データセット
uspto-grants-2013_11
特許番号
US08586588B2

反応ノート

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