Sodium Methoxide → 5-chloro-4-methoxy-2-methoxymethyl-2H-pyridazin-3-one
反応式
Cl[C:2]1[C:3](=[O:12])[N:4]([CH2:9][O:10][CH3:11])[N:5]=[CH:6][C:7]=1[Cl:8].[CH3:13][O-:14].[Na+]>O1CCOCC1>[Cl:8][C:7]1[CH:6]=[N:5][N:4]([CH2:9][O:10][CH3:11])[C:3](=[O:12])[C:2]=1[O:14][CH3:13]参加物
4
実験手順
To a stirred solution of 4,5-dichloro-2-methoxymethyl-2H-pyridazin-3one (1.00 g, 4.78 mmol) in 1,4-dioxane (25 mL) at room temperature was added sodium methoxide (271 mg, 5.02 mmol). After 19 h, the reaction was added additional 271 mg of sodium methoxide and was continued to stir for 6 h. The reaction was filtered and the filtrate was concentrated to give 915 mg (93% crude) 5-chloro-4-methoxy-2-methoxymethyl-2H-pyridazin-3-one.
後処理
- filtrationThe reaction was filtered
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-fa4d8481a1aa4dc4b4bf68defd8c8680
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08586588B2
反応ノート
読み込み中…