HCID 54578953、化合物 → HCID 178448626、化合物
反応式
Br[C:2]1[C:7]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])=[CH:6][N:5]=[CH:4][N:3]=1.[F:13][C:14]1[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][C:15]=1[C:16]([N:18]=[C:19]=[S:20])=[O:17]>O1CCOCC1>[CH2:9]([N:8]1[C:7]2[CH:6]=[N:5][CH:4]=[N:3][C:2]=2[S:20]/[C:19]/1=[N:18]\[C:16](=[O:17])[C:15]1[CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=[CH:24][C:14]=1[F:13])[CH2:10][CH2:11][CH3:12]参加物
4
反応条件
- 温度
- 60 °C
実験手順
A mixture of product from Example 3A (270 mg, 1.17 mmol) and 2-fluoro-5-(trifluoromethyl)benzoyl isothiocyanate (322 mg, 1.29 mmol) in dioxane was heated at 60° C. for 12 hours. The mixture was then concentrated under reduced pressure and the residue was partitioned between ethyl acetate and saturated aqueous NaHCO3. The organic layer was washed with brine, dried with MgSO4, filtered, and concentrated under reduced pressure. The residue was purified by chromatography (hexanes-EtOAc 1:2) to afford 380 mg of the title compound. MS (ESI) m/z 399 (M+H)+.