Acetic Acid → 3-Amino-2,4-dichlorobenzoic acid

HRID 2042779ノート

反応式

HRID 2042779 の反応式
C([NH:4][C:5]1[C:6]([Cl:15])=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([OH:10])=[O:9])(=O)C.C(O)(=O)C>Cl>[NH2:4][C:5]1[C:6]([Cl:15])=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([OH:10])=[O:9]

参加物

4

反応物 2

HCID 176Acetic AcidHCID 198331103-Acetamido-2,4-dichlorobenzoic acid

生成物 1

HCID 152782343-Amino-2,4-dichlorobenzoic acid

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

3-Acetylamino-2,4-dichloro-benzoic acid (21.0 g, 84.6 mmol) is stirred in 6 M aq. HCl-solution (120 mL) and acetic acid (250 mL) at reflux for 24 h. The reaction mixture is cooled, concentrated, diluted with water and concentrated again. The residue is diluted with water, stirred under cooling and filtered. The filtercake is washed and dried to give the sub-title compound.

後処理

  1. temperatureThe reaction mixture is cooled
  2. concentrationconcentrated
  3. additiondiluted with water
  4. concentrationconcentrated again
  5. additionThe residue is diluted with water
  6. temperatureunder cooling
  7. filtrationfiltered
  8. washThe filtercake is washed
  9. customdried

出典と根拠

ORDレコード
ord-486f2d8238134060861cc810d3308658
出典データセット
uspto-grants-2013_11
特許番号
US08586604B2

反応ノート

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