Acetyl chloride → N-(6-Chloro-2-fluoro-3-methyl-phenyl)-acetamide
反応式
[C:1](Cl)(=[O:3])[CH3:2].[Cl:5][C:6]1[C:11]([NH2:12])=[C:10]([F:13])[C:9]([CH3:14])=[CH:8][CH:7]=1>C1(C)C=CC=CC=1>[Cl:5][C:6]1[C:11]([NH:12][C:1](=[O:3])[CH3:2])=[C:10]([F:13])[C:9]([CH3:14])=[CH:8][CH:7]=1参加物
4
実験手順
Acetylchloride (2.56 mL, 36.0 mmol) is added to a mixture of 6-chloro-2-fluoro-3-methyl-aniline (5.00 g, 31.3 mmol) and toluene (200 mL), additional toluene (50 mL) is added and the mixture is heated to reflux for 3 h. Then it is cooled with an ice bath and the formed precipitate is filtered off, washed with cold toluene and dried.
後処理
- additionis added
- temperaturethe mixture is heated
- temperatureto reflux for 3 h
- temperatureThen it is cooled with an ice bath
- filtrationthe formed precipitate is filtered off
- washwashed with cold toluene
- customdried
出典と根拠
- ORDレコード
- ord-079bad06eb7c40febf64cf771a99796f
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08586604B2
反応ノート
読み込み中…