N-[(2,4-dichloro-3-isothiocyanatophenyl)methyl]-2,2-dimethylpropanamide → HCID 178447329、化合物

HRID 2042833ノート

反応式

HRID 2042833 の反応式
[Cl:1][C:2]1[C:15]([N:16]=[C:17]=[S:18])=[C:14]([Cl:19])[CH:13]=[CH:12][C:3]=1[CH2:4][NH:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8].[NH2:20][C:21]1[C:22]([NH2:45])=[N:23][C:24]([O:40][CH2:41][CH:42]([F:44])[F:43])=[C:25]([CH:39]=1)[C:26]([NH:28][C@H:29]1[CH2:34][CH2:33][C@H:32]([C:35]([F:38])([F:37])[F:36])[CH2:31][CH2:30]1)=[O:27]>CN(C=O)C.O>[Cl:1][C:2]1[C:15]([NH:16][C:17]([NH:20][C:21]2[CH:39]=[C:25]([C:26](=[O:27])[NH:28][C@H:29]3[CH2:30][CH2:31][C@H:32]([C:35]([F:38])([F:36])[F:37])[CH2:33][CH2:34]3)[C:24]([O:40][CH2:41][CH:42]([F:43])[F:44])=[N:23][C:22]=2[NH2:45])=[S:18])=[C:14]([Cl:19])[CH:13]=[CH:12][C:3]=1[CH2:4][NH:5][C:6](=[O:11])[C:7]([CH3:8])([CH3:9])[CH3:10]

参加物

5

反応物 2

HCID 56840192N-[(2,4-dichloro-3-isothiocyanatophenyl)methyl]-2,2-dimethylpropanamideHCID 178507778HCID 178507778、化合物

生成物 1

HCID 178447329HCID 178447329、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

N-(2,4-Dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide (100 mg, 0.30 mmol) is added to 5,6-diamino-2-(2,2-difluoro-ethoxy)-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (120 mg, 0.30 mmol) in DMF (5 mL) and it is stirred at rt overnight. The reaction mixture is diluted with water, extracted with EtOAc, the organic layer is washed with water, dried and concentrated to give the sub-title compound.

後処理

  1. extractionextracted with EtOAc
  2. washthe organic layer is washed with water
  3. customdried
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-2c40ac2ab71f4611a0a8694859f8c515
出典データセット
uspto-grants-2013_11
特許番号
US08586604B2

反応ノート

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