O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 178508983、化合物

HRID 2042837ノート

反応式

HRID 2042837 の反応式
[F:1][C:2]([F:11])([F:10])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH2:9])[CH2:5][CH2:4]1.[OH:12][CH2:13][CH2:14][O:15][C:16]1[N:24]=[C:23]([NH2:25])[C:22]([N+:26]([O-:28])=[O:27])=[CH:21][C:17]=1[C:18](O)=[O:19].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>>[F:1][C:2]([F:10])([F:11])[C@H:3]1[CH2:4][CH2:5][C@H:6]([NH:9][C:18](=[O:19])[C:17]2[CH:21]=[C:22]([N+:26]([O-:28])=[O:27])[C:23]([NH2:25])=[N:24][C:16]=2[O:15][CH2:14][CH2:13][OH:12])[CH2:7][CH2:8]1

参加物

4

反応物 3

HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 667651902-(2-Hydroxy-ethoxy)-6-amino-5-nitro-nicotinic acidHCID 178511531HCID 178511531、化合物

生成物 1

HCID 178508983HCID 178508983、化合物

実験手順

trans-4-Trifluoromethyl-cyclohexylamine (285 mg, 1.40 mmol) and TEA (410 μl) are added successively to a mixture of 2-(2-hydroxy-ethoxy)-6-amino-5-nitro-nicotinic acid (360 mg, 1.33 mmol), TBTU (285 mg, 1.33 mmol) and TEA (195 μl) and it is stirred for 1.5 h. The mixture is concentrated filtered and purified via chromatography.

後処理

  1. concentrationThe mixture is concentrated
  2. filtrationfiltered
  3. custompurified via chromatography

出典と根拠

ORDレコード
ord-7bf69942637d43a795079e17577c6810
出典データセット
uspto-grants-2013_11
特許番号
US08586604B2

反応ノート

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