Hydrochloric Acid → 2-Amino-1-(3-thienyl)ethanone hydrochloride

HRID 2042927ノート

反応式

HRID 2042927 の反応式
[O:1]=[C:2]([C:12]1[CH:16]=[CH:15][S:14][CH:13]=1)[CH2:3][NH:4]C(=O)OC(C)(C)C.[ClH:17]>CCOCC>[ClH:17].[NH2:4][CH2:3][C:2]([C:12]1[CH:16]=[CH:15][S:14][CH:13]=1)=[O:1]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 67995722tert-Butyl 2-oxo-2-(thiophen-3-yl)ethylcarbamate

生成物 1

HCID 131054172-Amino-1-(3-thienyl)ethanone hydrochloride

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
0 °C

実験手順

To a mixture of tert-butyl 2-oxo-2-(thiophen-3-yl)ethylcarbamate (776 mg, 3.21 mmol) in Et2O (3 mL) was added a HCl solution (4.0 M in dioxane, 6 mL) at 0° C. After stirring at 0° C. for 10 min, the resulting mixture was allowed warmed up to room temperature and stirred for 2 h. The reaction mixture was evaporated under vacuum to provide the titled compound (570 mg, quantitative) as a white solid. MH+142.

後処理

  1. temperaturethe resulting mixture was allowed warmed up to room temperature
  2. stirringstirred for 2 h
  3. customThe reaction mixture was evaporated under vacuum

出典と根拠

ORDレコード
ord-796cdd55deca459e92e656de905d858e
出典データセット
uspto-grants-2013_11
特許番号
US08586550B2

反応ノート

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