Sodium Methoxide → HCID 57743037、化合物

HRID 2043652ノート

反応式

HRID 2043652 の反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[CH:9][C:10]([CH2:11][N:12]3[CH2:16][CH:15]([CH2:17][CH2:18][CH3:19])[CH2:14][C:13]3=[O:20])=[C:4]2[N:3]=1.[CH3:21][O-:22].[Na+]>CO>[CH3:21][O:22][C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[CH:9][C:10]([CH2:11][N:12]3[CH2:16][CH:15]([CH2:17][CH2:18][CH3:19])[CH2:14][C:13]3=[O:20])=[C:4]2[N:3]=1

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 15979675HCID 15979675、化合物

生成物 1

HCID 57743037HCID 57743037、化合物収率 53.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
80 °C

実験手順

To a solution of 1-[(5-chloropyrazolo[1,5-a]pyrimidin-3-yl)methyl]-4-propylpyrrolidin-2-one 205 (0.575 mmol, 1 eq, 0.22 g) in MeOH (10 ml) is added sodium methoxide (5.75 mmol, 10 eq, 0.4 g). The mixture is heated at 80° C. for 2 hours. The solvent is removed under reduce pressure, water is added and the resulting mixture is extracted with CH2Cl2. The organic phases are combined, and dried over MgSO4. Volatiles are removed under reduced pressure to afford 89 mg of 1-[(5-methoxypyrazolo[1,5-a]pyrimidin-3-yl)methyl]-4-propylpyrrolidin-2-one 208.

後処理

  1. customThe solvent is removed
  2. additionis added
  3. extractionthe resulting mixture is extracted with CH2Cl2
  4. dry with materialdried over MgSO4
  5. customVolatiles are removed under reduced pressure

出典と根拠

ORDレコード
ord-e72f9af347ab426b9c3512c6746165b9
出典データセット
uspto-grants-2013_11
特許番号
US08586623B2

反応ノート

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