Hydrochloric Acid → 922516-38-9

HRID 2043762ノート

反応式

HRID 2043762 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:9]=[CH:8][N:7]([CH:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)[N:6]=1)=[O:4].[ClH:23]>C(OCC)C>[ClH:23].[NH:13]1[CH2:14][CH2:15][CH:10]([N:7]2[CH:8]=[CH:9][C:5]([C:3]([O:2][CH3:1])=[O:4])=[N:6]2)[CH2:11][CH2:12]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 674641231,1-dimethylethyl 4-[3-(methoxycarbonyl)-1H-pyrazol-1-yl]-1-piperidinecarboxylate2 回

生成物 1

HCID 67461532922516-38-9

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

To a solution of 1,1-dimethylethyl 4-[3-(methoxycarbonyl)-1H-pyrazol-1-yl]-1-piperidinecarboxylate (300 mg, 0.97 mmol) (i.e. the product of Example 18, Step B) in 5 mL of diethyl ether was added a 2 M solution of hydrogen chloride in ether (4.85 mL, 9.7 mmol), and the reaction mixture was stirred for 5 h at room temperature. The reaction mixture was evaporated in vacuo, the resulting residue was dissolved in methanol and concentrated in vacuo. The residue was dried in high vacuum to give 200 mg of the title compound as a white solid.

後処理

  1. customThe reaction mixture was evaporated in vacuo
  2. dissolutionthe resulting residue was dissolved in methanol
  3. concentrationconcentrated in vacuo
  4. customThe residue was dried in high vacuum

出典と根拠

ORDレコード
ord-38ab3ed50a94420386ba56960e957749
出典データセット
uspto-grants-2013_11
特許番号
US08586611B2

反応ノート

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