Triethylamine → (R)-6-(3-(3-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)ureido)piperidin-1-yl)-2-(4-(morpholine-4-carbonyl)phenylamino)nicotinamide

HRID 2044041ノート

反応式

HRID 2044041 の反応式
[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]2[CH:16]=[CH:15][C:11]([C:12]([NH2:14])=[O:13])=[C:10]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]([N:26]4[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)=[O:25])=[CH:20][CH:19]=3)[N:9]=2)[CH2:3]1.[CH:32]1([C:35]2[S:39][C:38]([NH:40][C:41](=O)[O:42]C3C=CC=CC=3)=[N:37][N:36]=2)[CH2:34][CH2:33]1.CCN(CC)CC>C(Cl)Cl>[CH:32]1([C:35]2[S:39][C:38]([NH:40][C:41](=[O:42])[NH:1][C@@H:2]3[CH2:7][CH2:6][CH2:5][N:4]([C:8]4[CH:16]=[CH:15][C:11]([C:12]([NH2:14])=[O:13])=[C:10]([NH:17][C:18]5[CH:19]=[CH:20][C:21]([C:24]([N:26]6[CH2:31][CH2:30][O:29][CH2:28][CH2:27]6)=[O:25])=[CH:22][CH:23]=5)[N:9]=4)[CH2:3]3)=[N:37][N:36]=2)[CH2:34][CH2:33]1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 19227158Phenyl 5-cyclopropyl-1,3,4-thiadiazol-2-ylcarbamateHCID 49846316(R)-6-(3-aminopiperidin-1-yl)-2-(4-(morpholine-4-carbonyl)phenylamino)nicotinamide

生成物 1

HCID 66833002(R)-6-(3-(3-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)ureido)piperidin-1-yl)-2-(4-(morpholine-4-carbonyl)phenylamino)nicotinamide収率 50.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A suspension of (R)-6-(3-aminopiperidin-1-yl)-2-(4-(morpholine-4-carbonyl)phenylamino)nicotinamide (40 mg, 0.094 mmol), phenyl 5-cyclopropyl-1,3,4-thiadiazol-2-ylcarbamate (29.5 mg, 0.113 mmol), and Et3N (0.016 mL, 0.113 mmol) in CH2Cl2 (2 mL) was stirred at rt overnight. The reaction mixture was diluted with CH2Cl2, washed with water, and concentrated. The residue was purified by prep-HPLC. The product containing fractions were collected, neutralized with saturated NaHCO3, extracted with CH2Cl2, separated, and concentrated to give 28 mg of (R)-6-(3-(3-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)ureido)piperidin-1-yl)-2-(4-(morpholine-4-carbonyl)phenylamino)nicotinamide as a light pink solid. LCMS: (M+H)+=592.18. 1H NMR (400 MHz, CDCl3-MIX) δ ppm 11.09 (1H, s), 7.59 (2H, d, J=8.79 Hz), 7.55 (1H, d, J=9.23 Hz), 7.24-7.28 (2H, m), 6.04 (1H, d, J=8.79 Hz), 3.93 (1H, dd, J=13.18, 3.08 Hz), 3.73-3.86 (2H, m), 3.53 (7H, d, J=6.15 Hz), 3.31-3.41 (1H, m), 3.22-3.31 (2H, m), 2.11-2.21 (1H, m), 1.90-2.00 (1H, m), 1.67-1.79 (1H, m), 1.51-1.65 (2H, m), 1.03-1.12 (2H, m), 0.89-0.96 (2H, m).

後処理

  1. washwashed with water
  2. concentrationconcentrated
  3. customThe residue was purified by prep-HPLC
  4. additionThe product containing fractions
  5. customwere collected
  6. extractionextracted with CH2Cl2
  7. customseparated
  8. concentrationconcentrated

出典と根拠

ORDレコード
ord-9bcb5a8546de46cdbb76e4392eb14e3c
出典データセット
uspto-grants-2013_11
特許番号
US08586751B2

反応ノート

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