Dimethylamine → 6-Chloro-N,N-dimethyl-4-(1-piperazinyl)-3-pyridazinamine
反応式
Cl[C:2]1[N:3]=[N:4][C:5]([Cl:14])=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.[CH3:15][NH:16][CH3:17]>CO>[Cl:14][C:5]1[N:4]=[N:3][C:2]([N:16]([CH3:17])[CH3:15])=[C:7]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:6]=1参加物
4
実験手順
23 g 3,6-dichloro-4-piperazin-1-yl-pyridazine and 45 g dimethylamine are suspended in 200 ml of methanol and autoclaved for 4 hours at 100° C. The reaction mixture is evaporated to dryness and the product is extracted with chloroform and washed with sodium hydroxide solution. The hydrochloride is precipitated with an ethereal HCl solution. 27 g product are obtained. M.p.=291° C.
後処理
- customThe reaction mixture is evaporated to dryness
- extractionthe product is extracted with chloroform
- washwashed with sodium hydroxide solution
- customThe hydrochloride is precipitated with an ethereal HCl solution
出典と根拠
- ORDレコード
- ord-6e4f4c0e2ecd4e0e96da19bee676c9b8
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08592400B2
反応ノート
読み込み中…