2-Amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one → 2-Amino-7-(2-methoxy-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one

HRID 2046476ノート

反応式

HRID 2046476 の反応式
[C:1]([CH:4]1[C:9](=[O:10])[CH2:8][CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH3:18])[CH2:6][C:5]1=O)(=O)[CH3:2].[NH2:20][C:21]1[N:30]=C(C)C2C(=O)CC(C3C=CC(F)=CC=3)CC=2[N:22]=1>>[NH2:30][C:21]1[N:22]=[C:1]([CH3:2])[C:4]2[C:9](=[O:10])[CH2:8][CH:7]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[O:17][CH3:18])[CH2:6][C:5]=2[N:20]=1

参加物

3

反応物 2

HCID 172212082-Amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-oneHCID 183173522-Acetyl-5-(2-methoxyphenyl)cyclohexane-1,3-dione

生成物 1

HCID 582693972-Amino-7-(2-methoxy-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one

実験手順

The title compound was prepared from 2-acetyl-5-(2-methoxy-phenyl)-cyclohexane-1,3-dione (872 mg, 3.35 mmol), from stage 1, following the procedure describing the synthesis of 2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one (example 3/a stage 2/3) except that the title compound was further purified by recrystallisation in methanol.

後処理

  1. customwas further purified by recrystallisation in methanol

出典と根拠

ORDレコード
ord-4ee409a49aab4f098ee2bb749a4387e7
出典データセット
uspto-grants-2013_11
特許番号
US08592430B2

反応ノート

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