化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → 2-Chloromaleic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Gantacurium | HCID 10102486 | — |
| 反応物 | Chlorofumarate | HCID 21982578 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-Chloromaleic acid | HCID 5284488 | — |
反応手順
Gantacurium, an asymmetrical chlorofumarate, was prepared in four chemical transformations from compound (XIIIB) using minor modifications of previously reported chemistry, see WO2005/041960. Isoquinolylalkanol compound (XIIIB) was condensed with trans-2,3-dichlorosuccinic anhydride and triethylamine in acetonitrile solvent to provide a monoester of chlorofumaric acid, which was then condensed with isoquinolylalkanol compound (XIIIC):
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08592451B2 |
| 出典データセット | uspto-grants-2013_11 |
| ORD ID | ord-bfa23cbf96724e8aae7a97aca570a95b |
| 出典メモ | uspto-grants-2013_11 |