Hydroxylamine → 2-Bromo-4-chloro-6-fluorobenzaldehyde oxime

温度

40 °C

To a solution of 2-bromo-4-chloro-6-fluoro-benzaldehyde (15 g, 63.16 mmol) in 2-propanol (130 ml) was added hydroxylamine (50% solution in water, 4.55 g, 68.90 mmol) at 25° C. and the mixture was warmed to 40° C. for 2 h. Water (55 ml) was then added slowly to this mixture and the slurry was aged for 1 h at 20° C. The reaction mixture was filtered and the remaining solid was washed with a mixture of 2-propanol and water (1.5:1) and dried under vacuum to yield the title compound (12.5 g, 77%) as white solid.

1. filtrationThe reaction mixture was filtered
2. washthe remaining solid was washed with a mixture of 2-propanol and water (1.5:1)
3. customdried under vacuum

ORDレコード

ord-664f97abdb2b4ccfa812b43145cecc9f

出典データセット

uspto-grants-2013_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08592426B2