Lithium Carbonate → HCID 59370522、化合物
反応式
[Cl:1][C:2]1[C:9]([Cl:10])=[C:8](F)[C:7]([CH3:12])=[CH:6][C:3]=1[C:4]#[N:5].[OH:13][C@H:14]1[CH2:18][CH2:17][NH:16][C@H:15]1[CH3:19].C(=O)([O-])[O-].[Li+].[Li+]>>[Cl:1][C:2]1[C:9]([Cl:10])=[C:8]([N:16]2[CH2:17][CH2:18][C@H:14]([OH:13])[C@@H:15]2[CH3:19])[C:7]([CH3:12])=[CH:6][C:3]=1[C:4]#[N:5]参加物
4
実験手順
Using 2,3-dichloro-4-fluoro-5-methylbenzonitrile (1.02 g), 0.9 M-dimethyl sulfoxide solution (5.56 ml) of (2S,3S)-3-hydroxy-2-methylpyrrolidine and lithium carbonate (370 mg), the title compound was obtained as a colorless solid (yield: 53 mg) by an operation similar to that in Example 3.
出典と根拠
- ORDレコード
- ord-88363441920f4a6f878587bc186b73f1
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08592452B2
反応ノート
読み込み中…