化工社化工社 化学情報印刷レポート · 研究参考用
1-Methyl-4-piperidone → 6-Bromo-1'-methylspiro[chroman-2,4'-piperidin]-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Methyl-4-piperidone | HCID 74049 | — |
| 反応物 | 5'-Bromo-2'-hydroxyacetophenone | HCID 95991 | — |
| 反応物 | (E)-3-{1'-tert-butoxycarbonyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester | HCID 52952087 | — |
| 生成物 | 6-Bromo-1'-methylspiro[chroman-2,4'-piperidin]-4-one | HCID 57720805 | — |
反応手順
1′-Methyl-6-bromo-spiro[chromane-2,4′-piperidine]-4-one was synthesized according to the procedure for the preparation of Intermediate 1, Step A, using N-methyl-4-piperidone (1.13 g, 10 mmol), and 2-hydroxy-5-bromoacetophenone to give an orange solid (2.29 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08592444B2 |
| 出典データセット | uspto-grants-2013_11 |
| ORD ID | ord-9b2838c094bb4140b84a07fc0d5496e0 |
| 出典メモ | uspto-grants-2013_11 |