Triethylamine → HCID 67494673、化合物

HRID 2047027ノート

反応式

HRID 2047027 の反応式
[CH:1]1([S:4](Cl)(=[O:6])=[O:5])[CH2:3][CH2:2]1.[Br:8][C:9]1[C:10]([O:29][CH2:30][CH:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)=[N:11][C:12]2[N:13]([N:16]=[CH:17][C:18]=2[C:19]2[CH:20]=[N:21][C:22]3[C:27]([CH:28]=2)=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:14]=1[NH2:15].C(N(CC)CC)C>CN(C=O)C>[Br:8][C:9]1[C:10]([O:29][CH2:30][CH:31]2[CH2:32][CH2:33][N:34]([S:4]([CH:1]3[CH2:3][CH2:2]3)(=[O:6])=[O:5])[CH2:35][CH2:36]2)=[N:11][C:12]2[N:13]([N:16]=[CH:17][C:18]=2[C:19]2[CH:20]=[N:21][C:22]3[C:27]([CH:28]=2)=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:14]=1[NH2:15]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 2760919Cyclopropanesulfonyl chlorideHCID 67494200HCID 67494200、化合物

生成物 1

HCID 67494673HCID 67494673、化合物収率 34.7%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Cyclopropanesulfonyl chloride (24 mg, 0.167 mmol) was added into a solution of 6-bromo-5-(piperidin-4-ylmethoxy)-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine (50 mg, 0.111 mmol) and triethylamine (56 mg, 0.553 mmol) in DMF at room temperature. The resulting reaction mixture was stirred at room temperature for 16 h, concentrated and purified by prep-LC to afford the title compound (21.5 mg): LC/MS RT=4.17 min. Mass calculated for, M+H 557.09, observed 557.09.

後処理

  1. customThe resulting reaction mixture
  2. concentrationconcentrated
  3. custompurified by prep-LC

出典と根拠

ORDレコード
ord-07518cd76a60469ba7bdabc0720406bb
出典データセット
uspto-grants-2013_11
特許番号
US08591943B2

反応ノート

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