N-Methylisobutylamine → 2-(Isobutyl-methyl-amino)-6-methyl-isonicotinic acid

HRID 2047273ノート

反応式

HRID 2047273 の反応式
[CH3:1][N:2]([CH3:13])[C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([CH3:12])[N:11]=1)[C:6]([OH:8])=[O:7].Cl[C:15]1[CH:16]=[C:17](C=C(C)N=1)C(O)=O.C(NC)C(C)C>>[CH2:1]([N:2]([CH3:13])[C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([CH3:12])[N:11]=1)[C:6]([OH:8])=[O:7])[CH:16]([CH3:17])[CH3:15]

参加物

4

反応物 3

HCID 12249N-MethylisobutylamineHCID 1412092-Chloro-6-methylpyridine-4-carboxylic acidHCID 179213472-(Dimethylamino)-6-methylpyridine-4-carboxylic acid

生成物 1

HCID 584180962-(Isobutyl-methyl-amino)-6-methyl-isonicotinic acid

実験手順

The title compound is prepared in analogy to 2-dimethylamino-6-methyl-isonicotinic acid starting from 2-chloro-6-methyl-isonicotinic acid and using isobutyl-methyl-amine; LC-MS: tR=0.61 min, [M+H]+=223.10.

出典と根拠

ORDレコード
ord-a68be34c48c74aef97a90d1bcdd5774d
出典データセット
uspto-grants-2013_11
特許番号
US08592460B2

反応ノート

読み込み中…