HCID 59355026、化合物 → 3-Amino-2-benzylpropanoic acid
反応式
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[CH2:12][C:13]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)(CC(OCC)=O)[C:14]([O:16]CC)=[O:15]>Cl.CC(O)=O>[NH2:3][CH2:12][CH:13]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:14]([OH:16])=[O:15]参加物
4
反応条件
- 温度
- 120 °C
実験手順
A solution of diethyl 2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-2-(phenylmethyl)butanedioate (13 g, 31.8 mmole) in conc. HCl (125 mL) and HOAc (30 mL) was sealed in a 1 L screwcap reaction vessel and the contents heated to 120° C. for 48 h. The reaction solution was concentrated under vacuum and the resulting solids washed with Et2O affording the title compound (quant.) as a white solid: LCMS (ES) m/z 181(M+H)+.
後処理
- concentrationThe reaction solution was concentrated under vacuum
- washthe resulting solids washed with Et2O affording the title compound (quant.) as a white solid
出典と根拠
- ORDレコード
- ord-3727fd93e2974e2cb6a416656649ad82
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08592475B2
反応ノート
読み込み中…