N-(2-amino-phenyl)-5-bromo-2-fluoro-benzamide → 2-(5-Bromo-2-fluoro-phenyl)-1H-benzoimidazole
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=O)[C:10]1[CH:15]=[C:14]([Br:16])[CH:13]=[CH:12][C:11]=1[F:17]>C(O)(=O)C>[Br:16][C:14]1[CH:13]=[CH:12][C:11]([F:17])=[C:10]([C:9]2[NH:8][C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[N:1]=2)[CH:15]=1参加物
3
反応条件
- 温度
- 60 °C
実験手順
A suspension of N-(2-amino-phenyl)-5-bromo-2-fluoro-benzamide (5.64 g, 18.3 mmol) in acetic acid (20 mL) was heated at 60° C. After 30 min, the suspension became a solution and it was left overnight. The solvent was removed under reduced pressure and residue was triturated with DCM (10 mL) and filtered off. The precipitate was washed with DCM (3×10 mL) and dried to afford 4.76 g of the title compound (89%).
後処理
- waitwas left overnight
- customThe solvent was removed under reduced pressure and residue
- customwas triturated with DCM (10 mL)
- filtrationfiltered off
- washThe precipitate was washed with DCM (3×10 mL)
- customdried
出典と根拠
- ORDレコード
- ord-a0020226a2894bd2a1ecc68c4a8d1139
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08592463B2
反応ノート
読み込み中…