Isopropanol hydrochloride → 1218764-02-3

反応式

[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([N:13](C)[C:14](=O)OC(C)(C)C)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[ClH:24].CC(O)C>>[ClH:24].[CH3:14][NH:13][C:5]1[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=[C:3]([C:2]([F:1])([F:22])[F:23])[CH:4]=1

参加物

反応物 2

HCID 21912024Isopropanol hydrochloride

HCID 86655660HCID 86655660、化合物

生成物 1

HCID 866556611218764-02-3収率 93%

反応条件

温度: 50 °C

実験手順

To the compound (12.4 g) obtained in step 2 was added 2N hydrogen chloride/2-propanol (100 mL), and the mixture was stirred at 50° C. for 2 hr. The reaction mixture was concentrated under reduced pressure to give the title compound (9.36 g, 93%) as a white powder.

後処理

concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード: ord-00db87f2bb534e219705fd03a03b16a4
出典データセット: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08592454B2

反応ノート

読み込み中…

参加物