Hydrochloric Acid → Ethyl 2,2-dimethylbutanoate

HRID 2047642ノート

反応式

HRID 2047642 の反応式
Cl.[CH3:2][C:3]([CH3:9])([CH2:7][CH3:8])[C:4]([OH:6])=[O:5].O.[CH2:11](O)[CH3:12]>>[CH2:11]([O:5][C:4](=[O:6])[C:3]([CH3:9])([CH3:2])[CH2:7][CH3:8])[CH3:12]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 962WaterHCID 116842,2-Dimethylbutanoic acid

生成物 1

HCID 12647075Ethyl 2,2-dimethylbutanoate

実験手順

Add 0.2 mL of concentrated hydrochloric acid to 2,2-dimethyl-butanoic acid (5.0 g, 43.0 mmol) in ethanol (43 mL) and heat to reflux for 5 hours. Cool to room temperature. Pour the reaction into water and extract with diethyl ether. Wash the combined organics with saturated aqueous sodium bicarbonate and water, dry over magnesium sulfate, filter, and concentrate under reduced pressure to afford the title compound which was used without further purification (4.0 g, 64.4%): 1H NMR (CDCl3) δ 0.82 (t, 3H, 1.14 (s, 3H), 1.23 (t, 3H), 1.55 (q, 2H), 4.1 (q, 2H).

後処理

  1. temperatureheat
  2. temperatureto reflux for 5 hours
  3. additionPour
  4. extractionextract with diethyl ether
  5. washWash the combined organics with saturated aqueous sodium bicarbonate and water
  6. dry with materialdry over magnesium sulfate
  7. filtrationfilter
  8. concentrationconcentrate under reduced pressure

出典と根拠

ORDレコード
ord-59e87af6c13d4a4197ab5e5aa2efb6b9
出典データセット
uspto-grants-2013_11
特許番号
US08592590B2

反応ノート

読み込み中…