Dimethylformamide → 1-Bromo-5-(but-3-enyloxy)-2,4-dimethylbenzene

HRID 2047947

反応式

HRID 2047947 の反応式
[Br:1][C:2]1[C:3]([CH3:10])=[CH:4][C:5]([CH3:9])=[C:6]([OH:8])[CH:7]=1.CN(C)C=O.C(=O)([O-])[O-].[K+].[K+].Br[CH:23]=[CH:24][CH2:25][CH3:26]>O>[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH2:26][CH2:25][CH:24]=[CH2:23])[C:5]([CH3:9])=[CH:4][C:3]=1[CH3:10]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 359451-Bromobut-1-eneHCID 126177325-Bromo-2,4-dimethylphenol

生成物 1

HCID 594796111-Bromo-5-(but-3-enyloxy)-2,4-dimethylbenzene

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
95 °C

実験手順

A 250-mL round bottomed flask is charged with 5-bromo-2,4-dimethylphenol (3.135 g, 15.6 mmol) and dimethylformamide (DMF) (50 mL). Potassium carbonate (23.7 g, 172 mmol) and bromobutene (15.8 mL, 156 mmol) are added and the reaction mixture is heated to 95° C. for 2 hr. After cooling to room temp, water (200 mL) is added. The product is extracted into ether (2×100 mL), and the combined organic fractions are washed with brine, dried over sodium sulfate and dried in vacuo. Yield=3.63 g (91.3%) of light yellow liquid.

後処理

  1. temperatureAfter cooling to room temp
  2. extractionThe product is extracted into ether (2×100 mL)
  3. washthe combined organic fractions are washed with brine
  4. dry with materialdried over sodium sulfate
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-eba2d7c18d024c388c7a982b46f758d0
出典データセット
uspto-grants-2013_11
特許番号
US08592615B2

関連ノート

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