Ethanol → 5-Methyl-2,3-dihydro-1-benzofuran-7-amine

HRID 2047974ノート

反応式

HRID 2047974 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]2[O:9][CH:8]=[CH:7][C:6]=2[CH:10]=1.C(O)C>ClCCl.[C].[Pd]>[CH3:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1

参加物

5

反応物 2

HCID 702EthanolHCID 552848275-Methylbenzofuran-7-amine

生成物 1

HCID 552848285-Methyl-2,3-dihydro-1-benzofuran-7-amine収率 87.6%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

5-Methylbenzofuran-7-ylamine (1.3 g, 8.8 mmol) and 10% palladium carbon (500 mg) were added to ethanol (50 ml), followed by conduction of catalytic reduction at room temperature under ordinary pressure. The catalyst was removed by celite filtration, and the obtained filtrate was condensed under reduced pressure. The residue was dissolved in dichloromethane, dried over anhydrous magnesium sulfate, and then concentrated to dryness under reduced pressure, giving a white powder of 5-methyl-2,3-dihydrobenzofuran-7-ylamine (1.15 g, yield: 87%).

後処理

  1. customfollowed by conduction of catalytic reduction at room temperature under ordinary pressure
  2. customThe catalyst was removed by celite filtration
  3. customcondensed under reduced pressure
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-86d4d71fdc3a44b6863b61629630334a
出典データセット
uspto-grants-2013_11
特許番号
US08592593B2

反応ノート

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