Cyclopropylboronic acid → HCID 58042362、化合物

HRID 2048086ノート

反応式

HRID 2048086 の反応式
[F:1][CH:2]([F:11])[O:3][C:4]1[C:5](Br)=[N:6][CH:7]=[CH:8][CH:9]=1.[CH:12]1(B(O)O)[CH2:14][CH2:13]1>>[F:1][CH:2]([F:11])[O:3][C:4]1[C:5]([CH:12]2[CH2:14][CH2:13]2)=[N:6][CH:7]=[CH:8][CH:9]=1

参加物

3

反応物 2

HCID 2760897Cyclopropylboronic acidHCID 580424482-broMo-3-(difluoroMethoxy)pyridine

生成物 1

HCID 58042362HCID 58042362、化合物収率 58%

反応条件

温度
95 °C

実験手順

Prepared according to Preparation 48 using 3-difluoromethoxy-2-bromopyridine (Preparation 217) and cyclopropylboronic acid. The reaction was heated to 95° C. for 18 hours before cooling to room temperature and filtering through arbocel. The filtrate was concentrated in vacuo and purified using silica gel column chromatography eluting with ethylacetate:heptane 1:5 to furnish the title compound as a colourless oil (273 mg, 58%).

後処理

  1. customPrepared
  2. temperaturebefore cooling to room temperature
  3. filtrationfiltering through arbocel
  4. concentrationThe filtrate was concentrated in vacuo
  5. custompurified
  6. washeluting with ethylacetate:heptane 1:5

出典と根拠

ORDレコード
ord-79a046edaf4f4bf7a1ebb93ad6927f28
出典データセット
uspto-grants-2013_11
特許番号
US08592629B2

反応ノート

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