Hydrochloric Acid → 2-(5-Piperidin-4-yl-4h-1,2,4-triazol-3-yl)-pyridine dihydrochloride
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[NH:11][N:10]=[C:9]([CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)[N:8]=1.[ClH:25]>CO.O1CCOCC1>[ClH:25].[ClH:25].[NH:15]1[CH2:16][CH2:17][CH:12]([C:9]2[N:8]=[C:7]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)[NH:11][N:10]=2)[CH2:13][CH2:14]1参加物
5
実験手順
To a solution of tert-butyl 4-[5-(pyridin-2-yl)-1H-1,2,4-triazol-3-yl]piperidine-1-carboxylate 39 g (111 mM) in methanol 50 is added 100 ml solution of HCl in dioxane and stirred at room temperature for 3 hrs. Solid precipitated is then filtered and washed with cold acetonitrile to obtained 2-[3-(piperidin-4-yl)-1H-1,2,4-triazol-5-yl]pyridine dihydrochloride as white solid.
後処理
- customSolid precipitated
- filtrationis then filtered
- washwashed with cold acetonitrile
出典と根拠
- ORDレコード
- ord-7d49beb97b4d4aab8cc31c60e692ecb4
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08592591B2
反応ノート
読み込み中…