Ethyl 2-[(2'-cyanobiphenyl-4-yl)methyl]-3-oxohexanoate → HCID 67008513、化合物

HRID 2048249

反応式

HRID 2048249 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([C:22](=O)[CH2:23][CH2:24][CH3:25])[C:17](OCC)=[O:18])=[CH:11][CH:10]=1)#[N:2].[CH3:27][O:28][CH:29]1[CH2:34][CH2:33][CH2:32][CH2:31][CH:30]1[NH:35][C:36]1[NH:40][C:39]([CH3:41])=[N:38][N:37]=1>>[CH3:27][O:28][CH:29]1[CH2:34][CH2:33][CH2:32][CH2:31][CH:30]1[N:35]1[C:17](=[O:18])[C:16]([CH2:15][C:12]2[CH:13]=[CH:14][C:9]([C:4]3[C:3]([C:1]#[N:2])=[CH:8][CH:7]=[CH:6][CH:5]=3)=[CH:10][CH:11]=2)=[C:22]([CH2:23][CH2:24][CH3:25])[N:37]2[N:38]=[C:39]([CH3:41])[N:40]=[C:36]12

参加物

3

反応物 2

HCID 10020734Ethyl 2-[(2'-cyanobiphenyl-4-yl)methyl]-3-oxohexanoateHCID 178489584HCID 178489584、化合物

生成物 1

HCID 67008513HCID 67008513、化合物収率 46%

反応条件

温度
250 °C

実験手順

A mixture of ethyl 2-[(2′-cyanobiphenyl-4-yl)methyl]-3-oxohexanoate (0.83 g) and N-(2-methoxycyclohexyl)-5-methyl-4H-1,2,4-triazol-3-amine (0.25 g) was stirred at 250° C. for 15 min under microwave irradiation. The obtained reaction mixture was purified by silica gel column chromatography to give the title compound as a colorless solid (0.27 g, 46%).

後処理

  1. customThe obtained reaction mixture
  2. customwas purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-eb57ea2519014c1f9b11941bc0b70a47
出典データセット
uspto-grants-2013_11
特許番号
US08592431B2

関連ノート

読み込み中…